29-Sep-2021 | Market Research Store
Certain bacterial species can form a robust and impermeable coating, also referred to as biofilm, around surgical implants including dental and other orthopedic implants. This is a huge concern in the global healthcare system. Antibacterial characteristics can be acquired from a number of hydrophobic compounds and drugs. However, these compounds must adhere to a material in order to withstand close to a targeted region within the body. Binding the pharmaceutically active compounds around graphene is a straightforward technique that might be easily implemented on a commercial level.
In this case, graphene shows prominent interaction for hydrophobic compounds or medications. With the help of ultrasound, the drug molecules were forced to bound to the graphene. Initially, the usnic acid coating was applied on the graphene surface, as the acid possesses antibacterial characteristics. Its mode of action involves inhibiting bacteria to synthesize nucleic acids, particularly RNA, and thereby impeding protein synthesis in the cell.
The two leading strains of pathogenic bacteria forming a biofilm on medical implants; Staphylococcus aureus and Staphylococcus epidermidis were examined by the researchers for resistance to usnic acid. The recently developed novel material holds a wide range of promising characteristics such as it releases molecules of usnic acid consistently and systematically, which eventually inhibits the formation of biofilms on the surface. The team found that by integrating usnic acid into the graphene’s surface, the results were remarkable.
The outcomes suggest that linking hydrophobic compounds with graphene is a basic process. It paves new opportunities in developing novel biomedical items that would deliver more effective antibacterial protection. The researchers are currently working on trials to see if they can link other drugs and hydrophobic molecules that have an improved ability to address or prevent several types of clinical illnesses.
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