Gut Check Gets More Realistic Using The New Intestine Mimicking Device

Gut Check Gets More Realistic Using The New Intestine Mimicking Device

Published: 11-Jan-2021 | Published By: Market Research Store

Researchers from Baylor College of Medicine and Rice University have discovered a new means toreplicate the conditions observed in intestines in order to understand the growth and progression rate of bacterial infections on a real-time basis.They successfully created a lab tool that easily mimics the human intestine and thereby provides the much needed evidence to gain better understanding of infectious diseases like diarrhea, amoebic infection, etc. According to bioengineer Jane Grande-Allen from Rice the development of translucent millifluidic perfusion cassettes (mPCs) was found to help easily operate and attune with the generally used biochemical and microscopic analysis. This new cassette invention could even be used by the non-bioengineers as the micro-scale ports help in and out flowing of both the fluid but also the sample.

Gut has always being a complicated part of the human body which the researchers have long been trying to replicate. The devices used for studying the gut are usually non-user-friendly. However, the latest device is easy-to-use not only for the medical researchers but also engineers. Moreover, maintaining themicrofluidic system without any leakage is a technical challenge and also mimicking its rate of flow compared to blood is slower. The new device is almost like the standard 96-well plates that were tested using human intestinal enteroids (HIEs) containing cultures of intestinal epithelium and fluid-containing bacteria.

The assessment of how well bacteria stick to and taint the cells, both visually and by practicallyusing the ports on both ends could be easily observed using mPCs. The observation could thus be more extended and realistic using this new device. Additionally, the testing helped researchers discover the aggregative adherence fimbriae, which are the sticky appendages present in majority of the infectious enteroaggregative Escherichia coli (EAEC).However, the basic goal was to flush out the bacterial toxins without damaging the healthy cells which, in turn, increased cell survival rate by changing the kind of film formed, providing necessary oxygen and nutrients, and eying interaction between the cells and invading pathogens.

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