31-May-2021 | Market Research Store
The latest research regarding food containing high unsaturated fats may provide an additional layer of protection against cardiovascular diseases. Researchers in Keenan Research Center for Biomedical Science(KRCBS) discovered that Apolipoprotein A-IV, otherwise known as ApoA-IV is a plasma protein and high concentration of the lipid through digested foods can lower rates of cardiovascular diseases significantly. They further concluded that ApoA-IV is an inhibitory factor for an increase in platelets – which are smaller blood cells that play a vital role in prevention of multiple diseases pertaining to bleeding disorders. The new findings by the research team at KRCBS indicate that ApoA-IV is a blocker of platelet surface glycoproteins GPIIblla(integrin αIIβ3).
Integrin αIIβ3 is a platelet receptor that makes it difficult for platelet to cluster together in a blood stream, which is known as platelet aggregation factor. Platelet aggregation is found to cause severe damage to the human form by blocking blood flow, increases chances of thrombosis, which is often quoted as the common disorder which leads to morbidity and mortality related diseases. Platelets often bind with a series of connecters. For one platelet to bind with another, a platelet receptor integrin αIIβ3 needs to bind with fibrinogen – a protein that bridges platelet in the blood.
The researchers explored the binding effect of ApoA-IV with regular intervals of food. After ever intake of a meal, platelets are simulated which makes the binding process a lot simpler and form white blood cells. ApoA-IV increases the amount of circulating blood almost instantly after consumption of a meal containing unsaturated fats and decreases the chances of platelet hyperactivity by a huge margin. This leads to a reduction in inflammation which further recedes toward a lower chance of mitigating a heart attack or a stoke. The study concludes that ApoA-IV possesses its own circadian rhythm and is the most active after overnight period and the least in the morning.