New Class Of Molecules Could Actively Kill A Range Of Bacteria

New Class Of Molecules Could Actively Kill A Range Of Bacteria

Published: 11-Jan-2021 | Published By: Market Research Store

Team from Wistar Institute has found a new class of compound that distinctively combine thereal-time rapid immune responsewith the antibiotic destroying of pan drug-resistant bacterial pathogens for directly attacking antimicrobial resistance (AMR). This study has been published in the Natureas there is an urgent need to fight AMR that is titled as a global public health threat by the World Health Organization (WHO).It is assumed that by 2050 the antibiotic-resistant infections could kill around 10 Million people and further enforce a $100 trillion burden on the global economy. There are currently a large number of bacteria that are growing resistant to antibiotic treatments. Thus, the need for a new class of antibiotic for lowering the chances of human health crisis is necessary.

The researchers have been creative to develop new class of molecules for killing the highly resistant bacteria that make treating infections difficult and also for enhancing the natural host immune response. According to the lead researcher Farokh Dotiwala from the Vaccine & Immunotherapy Center, he and his team has been able to identify a new generation of antimicrobials dubbed dual-acting immuno-antibiotics (DAIAs). This new molecule is found to target vital bacterial functions including metabolic pathways,nucleic acid & protein synthesis, and building of the cell membrane. However, the bacteria can dodge the molecule by mutating the target or inactivating the drug.

Surprisingly, the researchers have been able to study that the bacteria can be put in a confused situation by using the immune response along with the drug to make it hard for the bacteria to survive. Additionally, the team found a pathway namednon-mevalonate pathway ormethyl-D-erythritol phosphate (MEP) that is essential for the bacteria but absent in the humans to be ideal for the antibiotic development. The pathway helps synthesizeisoprenoids that is needed by the bacteria for its survival. Thus, inhibiting this enzyme can help target a wide range of bacteria.

Market Research Store has published a report on global antibacterial drug resistance market. The changing competitive market dynamics, geographical distribution, key market players, growth factors, opportunities & challenges, and market restraints are well fabricated in the report.