New In Vitro Living Lung Model Can Help Better Understand Coronavirus

New In Vitro Living Lung Model Can Help Better Understand Coronavirus

Published: 24-Nov-2020 | Published By: Market Research Store

Researchers from the Duke University havecreated anin vitrolive lung model that is an exact copy of the lung air sacs where coronavirus infection and other severe lung harm take place. This advance study has allowedthe researchers to see through the conflict between the SARS-CoV-2 coronavirus and lung cells at the optimum molecular scale. The virus completely destroys the delicate, ball-like air sacs called alveoli and causes pneumonia and acute respiratory distress which ultimately leads to death of the COVID-19 patients. However, the major drawback for the researchers is the lack of experimental systems that impersonate human lung tissues in the COVID research.

The Duke researchers have used lung organoids to developa model which is named as mini-lungs in a dish. The alveolar epithelial type-2 cells (AT2s)are stem cells that repair the damaged portions of the lungs and are also used to grow the organoids. Previously, the researchers showed the use of one AT2 cell to further multiply to produce millions of cells that arrange to form a balloon-like organoid similar to alveoli.However, the cow serum and other complex ingredients present in the medium also play an important role in triggering the cell growth.

The researchers tested many chemically pure factors to look for the best cluster computing entity. The basic goal is to obtain pure human organoid devoid of any helper cells. The mini-lungs are a breakthrough in the high throughput science as almost hundred experiments can be carried out continuously to screen new drugs or even to find self-defense chemicals produced in response to infection by the lung cells. The new model structure will help researchers explore not only SARS-CoV-2 but also other respiratory virus that affect lung cells. The mini-lungs through in-depth the gene activity and chemical signal study helped confirm that ACE2 cell surface receptor is home for the virus.

The infection is known to cause inflammatory response which led to formation of interferons and cytokine storm in response to the virus. All these cells in the long run cause self-destruction. Thus, the researchers are exploring if interferon suppression or regenerative medicine initiative could help better understand a new strain of SARS-CoV-2, D614G.

Market research Store has published a report on global in-vitro lung model market. The report accurately provides information linked to market valuation and changing market competitive dynamics.