Published: 24-Nov-2020 | Published By: Market Research Store
The Mayo Clinic has been able to confirm that about 15% of couples are infertile, and male infertility is observed in one-third of these cases. The major cause is the problem in sperm development. Recently, a team has reported in ACS Nano that there is a new way to deliver a protein vital for sperm cell production directly intothe testicles, in which it reestablished normal sperm development and permitted previously infertile subject to father. The male fertility is primarily due to the low sperm in the semen that resulted due to the damage to the blood-testis barrier (BTB). The barrier generally shields the reproductive cells from harmful toxicants or drugs using the protein named PIN1.
The researchers found the traditional therapies to treat male infertility to be risky as they could cause unwanted genetic changes in reproductive cells that might be passed onto offspring. Thus, the lead researcher Hyun-Mo Ryoo and his colleagues wanted to create a system to pass on proteins (like PIN1) as an alternativeto genes to the testes, but first they needed to spot a means to deliver proteins through the intricate tubes of the testicles and into cells. The researchers thus developed a new system named Fibroplex which comprised of silk fibroin based spherical nanoparticles and a lipid coating. The Fibroplex was loaded with PIN1 and the nanoparticles also showed no toxicity/testicular damage.
The PIN1-loaded Fibroplex when delivered into the testes showed the treatment to help restorealmost normal PIN1 levels, escalate sperm stem cell numbers, and also repaire the BTB. This new discovery of direct delivery of proteins is likely to help infertile males become fathers.
Market Research Store has published a report on global male infertility treatment market. The report touches upon the market analytics, opportunities, challenges, consumption rate, industrial strategies, regional development status, and development trends that have an impact on the market growth rate.
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