08-Jun-2021 | Market Research Store

The symptoms of COVID-19 arising in men are more serious compared to that in women owing to the lower androgen levels in the body of women. Androgen levels are strongly linked to the susceptibility of the SARS-CoV-2 pathogen. Androgen regulates two prominent surface membrane receptors, ACE2 &TMPRSS2, on the human ocular surface. The same receptors play important role in allowing the virus to get access into host cells.

According to a report published in the open-access journal iScience, the high prevalence of coronavirus infection can be declined by the administration of antiandrogens drugs such as Casodex in COVID-19 infected patients. This licensed drug is extensively used in the treatment of pancreatitis in Japan. Moreover, it helps in suppressing the action of TMPRSS2 receptor, thereby suppressing the rate of SARS-CoV-2 infection.

Researchers at Perlman School of Medicine claim that both ACE2 & TMPRSS2 receptors are the two indicators considered to precisely calculate the androgen levels. Hence, antiandrogens drug can inhibit these receptors in order to block the entry and decline the infection rate of the virus. The team conducted an in vitro experiment to prove the theory related to androgen receptors. The trial involved the monitoring of infection rate of the pseudo type of SAR-CoV-2 virus, which is not lethal. The viral culture was injected into the mice with low androgen levels. To drop the androgen levels to a negligible amount, the mice were injected with antiandrogens. As a result, the mice were devoid of androgen along with ACE2 and TMPRSS2 receptors. This experiment also proved that antiandrogen drugs can inhibit the spread of this viral infection in human beings as well.

The researchers are still working tirelessly to develop further novel and effective antiandrogen therapies that would decline the mortality rate of SAR-CoV-2 infected patients by 92%. The use of antiandrogen drugs can also minimize the time of hospitalization to nine days. Yet, researchers are planning to collaborate with microbiologists from Penn Centre to analyze the study using more lethal strains of the virus.