10-Sep-2021 | Market Research Store
The Kumamoto University researchers have recently published their findings that simulate the balance behind muscles and the resident stem cells (satellite cells) for muscle regeneration that have the ability to retain memory of their location in the human anatomy. This positional memory was previously thought to be based on the expressional pattern of the homebox (Hox) gene cluster which is the primary gene that is responsible for shaping the body during the fetal part of our cycle. The team believes that their findings can provide a clear pathway for exploring the pathogenesis of muscle diseases like muscle dystrophy and further help develop novel treatment solutions that are based on positional memory.
The team incorporated skeletal muscle and associated muscle cells that were isolated from the heads and limbs of adult mice and investigated the positional specificity at the epigenomic level using DNA methylome analysis methods. They concluded that certain characteristic differences in the DNA methylation status at the homebox loci. Among these found regions, A to D, the Hox-A locus in particular were found to possess an overall DNA hypermethylation state in the hind limbs a higher level of skeletal and muscle cells when compared to its counterpart.
Additionally, both skeletal muscle and muscle stem cells in the hind limbs showed higher expression of the Hox-A gene. These genes reflected the expression patterns during the fetal stage.The current batch of findings suggests that skeletal muscle and muscle stem cells go in tandem by remembering positional information during fetal life development, and the associating epigenomic regulation indicated by DNA methylation is certainly involved in the positional memory. Furthermore, the team concluded that they found evidence of the Hoxa10 gene which is highly expressed in the limb muscles. The team thenwent on to creating the lacking Hoxa10 gene in the muscle stem cells in order to analyze its functionality.
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https://www.marketresearchstore.com/market-insights/fetal-monitors-market-813392