14-Sep-2021 | Market Research Store

Research team from the Royal Institute of Technology has recently conducted an experiment that can simulate a well-designed and functional model for the brain-blood barrier. This model is an unprecedented step and could provide a deeper understanding of how antioxidants protect the brain from inflammatory measures that are caused by inheritance of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This study was conducted in order to understand the effects of how the brain-blood barrier reacts to higher levels of inflammation after the administration of a derivate that is commonly used for treating these diseases known an NAC (N-acetylcysteine).

The current level of testing of NACA (N-Acetylcysteine Amide) is being under observation for the first time in recorded history with human stem cell-derived cells that proceed to show the breakdown of the barrier under higher load of inflammatory measures. The team further concludes their findings as “rather more complex” than what the team hypothesized. They further quote that the results indicate that other forms of NAC compounds and antioxidants can offer a higher level of neuron protection against such conditions. The team extends the possibility that these results can provide further distinguishable evidence before testing drugs on animals before the possibility of a clinical trial.

The model in question is a two layered set-up where channels carry simulated blood and inflammation agents as well as anti-inflammatory drugs by compartmentalizing the perivascular space with the brain and the external vascular system in a mediated manner. The layer is held together by a membrane of cells that is extracted from the stem cells of a single patient and is held together by proteins. The cellular activity in this model is being regulated by electronic sensors that take measurements of any change every minute in the same manner the barrier reacts when exposed to stress in the same manner that a neurodegenerative diseases does.

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