15-Aug-2020 | Market Research Store
Researchers Hans Renata and Alexander Adibekian from Scripps Research together discovered a new method to efficiently create an artificial version of an efficient natural compound called cepafungin I. This compound is found to show anti-cancer properties. Basically, the researchers stated that the bacterial secretion could block the molecular machinery called proteasome. It is a usual strategy used by cancer medications to destroy tumor cells. The binding of cepafungin I on two places on the proteasome showcases its powerful outcome. This study was published in the journal Cell Chemical Biology.
This compound stimulates several downstream biological responses as the FDA-approved chemotherapy bortezomib. The antifungal properties of the compound are the major reason behind fascinating the researchers. The compound acts on the proteasomes which is the cell garbage clearer. The blocking of proteasome will kill the cells. However, its complex structure has made the use of the compound as a medication very challenging. The Scripps Research team synthesized the compound in 9 steps keeping the synthesis of glidobactin A as a landmark. The use of certain enzymes helped create an amino acid, lipid, and other branches of the compound.
After the development of the compound, the researchers found it to show no cross-reaction with other proteins plus having selective targeting sites and thereby, making it a perfect drug candidate. The side effects and development of resistance of FDA approved proteasome inhibitors—bortezomib, carfilzomib, and ixazomib—are the reason there is a need for an alternative substance. Furthermore, the use of chemoenzymatic synthesis (Renata lab) and chemoproteomics (Adibekian lab) aided in forming the compound. Meanwhile, the researchers plan to continue their hunt for compounds with potential anti-cancer activities. The researchers plan to further study the cepafungin I compound so as to turn it into an effective treatment for cancer.
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