Published: 20-Nov-2020 | Published By: Market Research Store
Leukemia stem cells are the ones that give rise to leukemia. These stem cells usually reside in a tumor stimulating and shielding niche located in the bone marrow. Recently a team of scientists from the Max Planck Institute of Biochemistry, Germany, has found a novel method to make these cells vulnerable by speciallyremoving these cells from their niches. Moreover, as the blood cells have a limited lifespan they are lost during bleeding or used at the time of infection. Thus, it is a must to have them replaced immediately. The continuous supply is maintained by hematopoietic stem cells in the bone marrow and these cells are programmed to form any type of blood cell.
It has been found that the hematopoietic stem cell suffers a genetic mutation through recombination between chromosome 9 and 22in chronic myeloid leukemia. Thus, the genes fuse which instead remain separate and this incorrect assembly of chromosomes called Philadelphia chromosome leads to the formation of BCR-ABL oncogene. It is the reason the leukemic stem cell starts behaving differently and dividesin contrary to the healthy blood stem cells. The malignant niche created by the leukemic stem cell helps confirm the survival and proliferation. In addition to stabilize the niche the stem cells use integrins to bind to a scaffold of extracellular proteins and adjacent cells. The Kindlin protein is known to help integrin function in the leukemic stem cell.
Interestingly, the researchers have found the leukemic stem cells to express a protein called CTLA-4 on their surface, which healthy blood stem cells lack. This major difference between a leukemic blood stem cell and a healthy blood stem cell helped researchers use aptamer(CTLA-4-binding RNA sequence) to deliver a Kindlin-3 destroying compound (siRNA) into leukemic stem cells. This new study can help destroy the leukemic stem cell.
Market Research Store has published a report on global leukemia therapeutics market. The report provides information including market analytics, opportunities & challenges, supply & demand rate, and development trends.
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