SMART Researchers Develop A New Feasible RBC Manufacturing Processes

SMART Researchers Develop A New Feasible RBC Manufacturing Processes

Published: 21-Sep-2020 | Published By: Market Research Store

A new way of manufacturing red blood cells (RBCs) within half the culture time of the presently used methods was developed by the team from Singapore-MIT Alliance for Research and Technology (SMART). The new method uses new sorting and purification techniques that are quick, accurate, and cost-effective. Across the world, there are millions who require blood transfusions but there are only limited blood supplies. In order to address this issue, the researchers have developed a new means of developing red blood cells for meeting the needs for the universal donor blood O+ as it is beneficial for people with conditions such as leukemia. Moreover, the increasing demand for large volumes and tedious cell isolation processes has encouraged for an alternative means for blood manufacturing. The dependence on blood banks across the globe and the donors could be reduced significantly through this easier and faster manufacturing process.

The new finding is critical for majority of the research on various blood-related infections and also for improving new cell therapies. The existing red blood cells manufacturing processes are time-consuming, produces unwanted by-products, expensive, and also invalid for large scale therapeutic uses. However, the new finding shows the designing of a standard intermediary cryogenic storage protocol that lowers cell culture time up to 11 Days after thawing compared to the earlier 23 Days of blood manufacturing. The new technology is extremely efficient, highly targeted sorting, and low-cost RBC purification.

The improvements being made in the RBCs production is a huge technical advancement made by the SMART’s researchers. In the traditional methods, RBCs grow within 23 Days but in the new technique the cells are grown in liquid nitrogen and after thawing within 11 Days the cells are ready. The new sorting and purification is a combination of the modified versions of Dean Flow Fractionation (DFF) and Deterministic Lateral Displacement (DLD) to production of RBCs. In majority of the cell deformable diseases like cancer there is a huge demand for immune cell sorting and diagnostics and this new technique seems to be exact remedy.

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