15-Sep-2021 | Market Research Store
The University of Keck School of Medicine of USC researchers have recently published a research paper that increases the odds of structuringmini-kidneys using stem cells. The team created a primary building block that can used for building a form of “synthetic kidney” to be used to generate rudimentary kidney structures that are known as organoids. These organoids function in the same manner of a duct collecting systems by maintaining the body’s fluid and pH balance by concentratingand transporting urine to and fro from the body. The team notes that the new kidney types made from the kidney organoidsare expected to provide powerful tools for not only development and disease study but also for finding new methods of novel treatments and therapeutics for regenerative approaches for a wider range of patients.
The team initialized their researchwith a population of cells known as ureteric bud progenitor cells or UPCs that play a pivotal role in early kidney development. Using a blend of mouse and human UPCs, the team played an important role indeveloping a virulent cocktail of molecules that encouraged cells for forming organoids that resemble these ureteric cells. These cells are the branching tubes that give rise to collecting “duct system”.
The team also devised a method for harboring a different form of cocktail that can be used to induce human cells to develop a natural way of structuring ureteric bud organoids. An additional format of ureteric bud organoids was devised from mouse UPCs or human stem cells to develop a reliable and mature duct organoids.The team quotes that human and mouse ureteric bud organoids can further be genetically manufactured for diseased patients by providing a better simulated model aimed at understanding kidney problems and screening a wider range of potential therapeutic drugs.
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https://www.marketresearchstore.com/market-insights/stem-cell-banking-market-786688