Yeast Might Ease The Large Scale Production Of Rare Natural Molecules

Currently, majority of the modern medicines such as opioids and analgesics are made using rare molecules present in bacteria and plants. And these medications are found effective against the majority of diseases. However, several medications have proven to be challenging in terms of large scale production. The production of medication are not only labor intensive but also uneconomical for majority of the pharmaceutical companies that are commercially producing them in sufficient amounts for the market. According to the study published in Nature Communications, the team from Concordia University has developed a new way of synthesizing complex bioactive molecules with an efficient and cost-effective approach.

Researchers believed the use of baker’s yeast which is a single-cell organism to be the suitable substitute in the drug development study as resembles a lot more too human cells. This new study provides a cutting-edge synthetic biology approach that can help produce benzylisoquinoline alkaloid (BIA) in large amounts. The new yeast-based platform is projected to aid in the production of an array of natural and new-to-nature chemical structures in the coming years. The new approach is a blueprint for the large-scale production of a number of medications such as the opioid analgesics morphine and codeine. Similarly, the opioid antagonists such as naloxone and naltrexone used in case of overdose and dependence could also be made using this new method.

Previously, the genetic code plants were used to obtain molecules for further use in the pharmaceutical industry. The transplanting of the plant genes or enzymes into the yeast for industrial production is still being used. But, the new technology platform can help produce the molecules on a large scale. The new technology is a huge relief for countries like Canada that have to import majority of the rare molecules used in the drugs. In addition, during the present fragile distribution chain the implication of yeast-based production is a relevant. It is assumed that the use of the new platform will aid in the commercialization and discovery of new drugs.

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https://www.marketresearchstore.com/report/global-bakers-yeast-market-report-2019-701598