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Bone Metabolism Therapeutics Market to 2018 - Hyperparathyroidism Sector to Decline in the Absence of New Product Launches and Increased Generic Erosion for Zemplar, Hectorol and Sensipar

Published: Jun-2012 | Format: PDF | GBI Research | Number of pages: 112 | Code: MRS - 1305

GBI Research, the leading business intelligence provider, has released its latest research, “Bone Metabolism Therapeutics Market to 2018 Hyperparathyroidism Sector to Decline in the Absence of New Product Launches and Increased Generic Erosion for Zemplar, Hectorol and Sensipar”, which provides insights into bone metabolic disease therapeutics until 2018. The report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GBI Research’s team of industry experts. The report provides an in-depth analysis of the major bone metabolic diseases, including osteoporosis, Paget’s disease of bone, hyperparathyroidism and bone metastases. The report also provides the share of generics in global bone metabolic diseases as well as in each indication market. It also provides the treatment algorithm flow for each of the four indications. The report examines the global bone metabolic diseases treatment usage patterns. In addition, the geographical distribution of bone metabolic diseases and markets across the US, the top five countries of Europe, and in Japan, are provided in the report. The report also includes insights into the bone metabolic diseases R&D product pipeline and explores the competitive landscape, including major players in the bone metabolism therapeutics market. Finally, the report also includes analysis of Mergers and Acquisitions (M&As) and licensing agreements that took place in the bone metabolism therapeutics market. 

GBI Research’s analysis shows that the overall global bone metabolism therapeutics market for the four indications (which includes osteoporosis, Paget’s disease of bone, hyperparathyroidism and bone metastases) was valued at $15 billion in 2010, growing from $10.1 billion in 2002 and indicating a CAGR of 5.2%. GBI Research forecasts the market to grow at a CAGR of 7.7% between 2010 and 2018 to record a sales value of $27.1 billion by 2018. The growth in the bone metabolism therapeutics market is mainly due to the contribution of osteoporosis market. The revenue of osteoporosis market alone has approximately 68% of the total bone metabolism revenue. So, the global bone metabolism market is growing inspite of the declining market nature of the rest of therapeutics areas discussed here.

Scope

  • Data and analysis on the metabolic disorder therapeutics market in the leading geographies of the world – the US, the UK, Germany, France, Italy, Spain, and Japan. 
  • Annualized market data for the metabolic disorder therapeutics market from 2002 to 2010, with forecasts to 2018 for the three indications – osteoporosis, Paget’s disease of bone, hyperparathyroidism and bone metastases.
  • Market data on the geographical landscape and therapeutic landscape, including market size, market share, annual cost of therapy, sales volume and treatment usage patterns such as disease population, treatment seeking population, diagnosis population and prescription population.
  • Share of the generics in the global bone metabolism therapeutics market and for the market of each indication that is covered in the report.
  • Key drivers and restraints that have had a significant impact on the market.
  • The competitive landscape of the global bone metabolism therapeutics market, including top companies benchmarking. The key companies studied in this report are Amgen Inc., Abbott Laboratories, Genzyme Corporation, Merck & Co. Inc. and Novartis AG.
  • Key M&A activities and Licensing Agreements that took place in 2009 and 2011 in the metabolic disorders therapeutics market.


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Table of Contents

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 9

2 Introduction 11

3 Bone Metabolism Therapeutics Market to 2018 - Market Overview 12
3.1 Introduction 12
3.1.1 Revenue 12
3.1.2 Annual Cost of Treatment 13
3.1.3 Treatment Usage Patterns 14

4 Bone Metabolism Therapeutics Market to 2018 - Geographical Landscape 16
4.1 Revenue Analysis by Geography 16
4.2 The US 18
4.2.1 Revenue 18
4.2.2 Annual Cost of Treatment 19
4.2.3 Treatment Usage Patterns 20
4.3 Top Five Countries of Europe 22
4.3.1 Revenue 22
4.3.2 Annual Cost of Treatment 24
4.3.3 Treatment Usage Patterns 25
4.4 Japan 27
4.4.1 Revenue 27
4.4.2 Annual Cost of Treatment 28
4.4.3 Treatment Usage Patterns 29

5 Bone Metabolism Therapeutics Market to 2018 - Therapeutic Landscape 31
5.1 Osteoporosis Therapeutics Market 31
5.1.1 Introduction 31
5.1.2 Revenue 31
5.1.3 Annual Cost of Treatment 35
5.1.4 Treatment Usage Patterns 36
5.1.5 Treatment Flow Algorithm 38
5.1.6 Drivers and Barriers for the Osteoporosis Therapeutics Market 39
5.2 Paget’s Disease of Bone Therapeutics Market 40
5.2.1 Introduction 40
5.2.2 Revenue 40
5.2.3 Annual Cost of Treatment 45
5.2.4 Treatment Usage Patterns 46
5.2.5 Treatment Flow Algorithm 48
5.2.6 Drivers and Barriers for the Paget’s Disease of Bone Therapeutics Market 49
5.3 Hyperparathyroidism Therapeutics Market 50
5.3.1 Introduction 50
5.3.2 Revenue 50
5.3.3 Annual Cost of Treatment 55
5.3.4 Treatment Usage Patterns 56
5.3.5 Treatment Flow Algorithm 58
5.3.6 Drivers and Barriers for the Hyperparathyroidism Therapeutics Market 59
5.4 Bone Metastases Therapeutics Market 60
5.4.1 Introduction 60
5.4.2 Revenue 60
5.4.3 Annual Cost of Treatment 65
5.4.4 Treatment Usage Patterns 66
5.4.5 Treatment Flow Algorithm 68
5.4.6 Drivers and Barriers for the Bone Metastases Therapeutics Market 68

6 Bone Metabolism Therapeutics Market to 2018 - Pipeline Analysis 70
6.1 Introduction 70
6.2 Bone Metabolism Therapeutics Market - Pipeline Assessment by Clinical Phase of Development 72
6.2.1 Filed Molecules 72
6.2.2 Phase III 73
6.2.3 Phase II 78
6.2.4 Phase I 80
6.2.5 Preclinical Phase 81
6.2.6 Discovery Phase 82
6.3 Profiles of Promising Molecules in the Bone Metabolism Therapeutics Market 82
6.3.1 Alpharadin (radium-223 chloride) 82
6.3.2 Orazol (Zoledronic acid) 83
6.3.3 Xgeva (denosumab) 83
6.3.4 Boniva (ibandronate sodium hydrate) 84
6.3.5 Odanacatib (odanacatib) 85
6.3.6 GTH-42V 85
6.3.7 Viviant (bazedoxifene) 86

7 Bone Metabolism Therapeutics Market to 2018 - Competitive Profiling 87
7.1 Competitive Profiling 87
7.1.1 Amgen Inc. 87
7.1.2 Abbott Laboratories 89
7.1.3 Genzyme Corporation 90
7.1.4 Merck & Co., Inc. 91
7.1.5 Novartis AG 93

8 Bone Metabolism Therapeutics Market to 2018 - Strategic Consolidations 95
8.1 Mergers and Acquisitions 95
8.1.1 Segmentation by Deal Value 97
8.1.2 Segmentation by Geography 99
8.2 Co-development Deals 100
8.2.1 Summary of Co-development Deals 101
8.3 Licensing Deals 102
8.3.1 Summary of Licensing Deals 103

9 Bone Metabolism Therapeutics Market to 2018 - Appendix 105
9.1 Market Definitions 105
9.2 Abbreviations 105
9.3 Sources 106
9.4 Research Methodology 106
9.4.1 Coverage 106
9.4.2 Secondary Research 107
9.4.3 Primary Research 107
9.5 Therapeutic Landscape 108
9.5.1 Epidemiology-based Forecasting 108
9.5.2 Market Size by Geography 110
9.6 Geographical Landscape 111
9.7 Pipeline Analysis 111
9.8 Competitive Landscape 111
9.8.1 Expert Panel Validation 111
9.9 Contact Us 111
9.10 Disclaimer 112


List of Tables

Table 1: Bone Metabolism Therapeutics Market, Global, Revenue ($bn), 2002-2010 12
Table 2: Bone Metabolism Therapeutics Market, Global, Revenue Forecasts ($bn), 2010-2018 12
Table 3: Bone Metabolism Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2010 13
Table 4: Bone Metabolism Therapeutics Market, Global, Annual Cost of Treatment ($), 2010-2018 13
Table 5: Bone Metabolism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2010 14
Table 6: Bone Metabolism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2010-2018 15
Table 7: Bone Metabolism Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2002-2010 17
Table 8: Bone Metabolism Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2010-2018 17
Table 9: Bone Metabolism Therapeutics Market, The US, Revenue ($bn), 2002-2010 18
Table 10: Bone Metabolism Therapeutics Market, The US, Revenue Forecasts ($bn), 2010-2018 18
Table 11: Bone Metabolism Therapeutics Market, The US, Annual Cost of Treatment ($), 2002-2010 19
Table 12: Bone Metabolism Therapeutics Market, The US, Annual Cost of Treatment ($), 2010-2018 19
Table 13: Bone Metabolism Therapeutics Market, The US, Treatment Usage Patterns (millions), 2002-2010 20
Table 14: Bone Metabolism Therapeutics Market, The US, Treatment Usage Patterns (millions), 2010-2018 21
Table 15: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Revenue ($bn), 2002-2010 22
Table 16: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Revenue Forecasts ($bn), 2010-2018 22
Table 17: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, by Geography, Revenue ($bn), 2002-2010 23
Table 18: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, by Geography, Revenue Forecasts ($bn), 2010-2018 23
Table 19: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Annual Cost of Treatment ($), 2002-2010 24
Table 20: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Annual Cost of Treatment ($), 2010-2018 24
Table 21: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Treatment Usage Patterns (millions), 2002-2010 25
Table 22: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Treatment Usage Patterns (millions), 2010-2018 26
Table 23: Bone Metabolism Therapeutics Market, Japan, Revenue ($bn), 2002-2010 27
Table 24: Bone Metabolism Therapeutics Market, Japan, Revenue Forecasts ($bn), 2010-2018 27
Table 25: Bone Metabolism Therapeutics Market, Japan, Annual Cost of Treatment ($), 2002-2010 28
Table 26: Bone Metabolism Therapeutics Market, Japan, Annual Cost of Treatment ($), 2010-2018 28
Table 27: Bone Metabolism Therapeutics Market, Japan, Treatment Usage Patterns (millions), 2002-2010 29
Table 28: Bone Metabolism Therapeutics Market, Japan, Treatment Usage Patterns (millions), 2010-2018 30
Table 29: Osteoporosis Therapeutics Market, Global, Revenue ($bn), 2002-2010 31
Table 30: Osteoporosis Therapeutics Market, Global, Revenue Forecasts ($bn), 2010-2018 32
Table 31: Osteoporosis Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2002-2010 32
Table 32: Osteoporosis Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2010-2018 33
Table 33: Osteoporosis Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2010 35
Table 34: Osteoporosis Therapeutics Market, Global, Annual Cost of Treatment ($), 2010-2018 35
Table 35: Osteoporosis Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2010 36
Table 36: Osteoporosis Therapeutics Market, Global, Treatment Usage Patterns (millions), 2010-2018 37
Table 37: Paget’s Disease of Bone Therapeutics Market, Global, Revenue ($m), 2002-2010 41
Table 38: Paget’s Disease of Bone Therapeutics Market, Global, Revenue Forecasts ($m), 2010-2018 41
Table 39: Paget’s Disease of Bone Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2010 42
Table 40: Paget’s Disease of Bone Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2010-2018 43
Table 41: Paget’s Disease of Bone Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2010 45
Table 42: Paget’s Disease of Bone Therapeutics Market, Global, Annual Cost of Treatment ($), 2010-2018 45
Table 43: Paget’s Disease of Bone Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2010 46
Table 44: Paget’s Disease of Bone Therapeutics Market, Global, Treatment Usage Patterns (millions), 2010-2018 47
Table 45: Hyperparathyroidism Therapeutics Market, Global, Revenue ($m), 2002-2010 51
Table 46: Hyperparathyroidism Therapeutics Market, Global, Revenue Forecasts ($m), 2010-2018 51
Table 47: Hyperparathyroidism Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2010 52
Table 48: Hyperparathyroidism Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2010-2018 53
Table 49: Hyperparathyroidism Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2010 55
Table 50: Hyperparathyroidism Therapeutics Market, Global, Annual Cost of Treatment ($), 2010-2018 55
Table 51: Hyperparathyroidism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2010 56
Table 52: Hyperparathyroidism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2010-2018 57
Table 53: Bone Metastases Therapeutics Market, Global, Revenue ($m), 2002-2010 61
Table 54: Bone Metastases Therapeutics Market, Global, Revenue Forecasts ($m), 2010-2018 61
Table 55: Bone Metastases Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2010 62
Table 56: Bone Metastases Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2010-2018 63
Table 57: Bone Metastases Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2010 65
Table 58: Bone Metastases Therapeutics Market, Global, Annual Cost of Treatment ($), 2010-2018 65
Table 59: Bone Metastases Therapeutics Market, Global, Treatment Usage Patterns (thousands), 2002-2010 66
Table 60: Bone Metastases Therapeutics Market, Global, Treatment Usage Patterns (thousands), 2010-2018 67
Table 61: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, NDA-filed Molecules,2011 72
Table 62: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, Phase III Molecules,2011 73
Table 63: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, Phase II Molecules,2011 78
Table 64: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, Phase I Molecules,2011 80
Table 65: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, Preclinical Phase Molecules,2011 81
Table 66: Bone Metabolism Therapeutics Market, Global, Pipeline Analysis, Discovery Phase Molecules,2011 82
Table 67: Bone Metabolism Therapeutics Market, Global, M&A, 2009-2011 96
Table 68: Bone Metabolism Therapeutics Market, M&A Deals, by Value ($m) 2009-2011 98
Table 69: Bone Metabolism Therapeutics Market, Co-development, by Geography, 2009-2011 100
Table 70: Bone Metabolism Therapeutics Market, Licensing Deals, by Geography, 2009-2011 102
List of Figures

Figure 1: Bone Metabolism Therapeutics Market, Global, Revenue Forecasts ($bn), 2002-2018 12
Figure 2: Bone Metabolism Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2018 13
Figure 3: Bone Metabolism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2018 14
Figure 4: Bone Metabolism Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2002-2018 16
Figure 5: Bone Metabolism Therapeutics Market, The US, Revenue Forecasts ($bn), 2002-2018 18
Figure 6: Bone Metabolism Therapeutics Market, The US, Annual Cost of Treatment ($), 2002-2018 19
Figure 7: Bone Metabolism Therapeutics Market, The US, Treatment Usage Patterns (millions), 2002-2018 20
Figure 8: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Revenue Forecasts ($bn), 2002-2018 22
Figure 9: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, by Geography, Revenue Forecasts ($bn), 2002-2018 23
Figure 10: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Annual Cost of Treatment ($), 2002-2018 24
Figure 11: Bone Metabolism Therapeutics Market, Top Five Countries of Europe, Treatment Usage Patterns (millions), 2002-2018 25
Figure 12: Bone Metabolism Therapeutics Market, Japan, Revenue Forecasts ($bn), 2002-2018 27
Figure 13: Bone Metabolism Therapeutics Market, Japan, Annual Cost of Treatment ($), 2002-2018 28
Figure 14: Bone Metabolism Therapeutics Market, Japan, Treatment Usage Patterns (millions), 2002-2018 29
Figure 15: Osteoporosis Therapeutics Market, Global, Revenue Forecasts ($bn), 2002-2018 31
Figure 16: Osteoporosis Therapeutics Market, Global, Revenue Analysis by Geography ($bn), 2002-2018 32
Figure 17: Osteoporosis Therapeutics Market, Global, Branded vs. Generic Share, 2010 and 2018 34
Figure 18: Osteoporosis Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2018 35
Figure 19: Osteoporosis Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2018 36
Figure 20: Osteoporosis Therapeutics Market, Treatment Flow Algorithm 38
Figure 21: Osteoporosis, Market Drivers and Barriers 39
Figure 22: Paget’s Disease of Bone Therapeutics Market, Global, Revenue Forecasts ($m), 2002-2018 41
Figure 23: Paget’s Disease of Bone Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2018 42
Figure 24: Paget’s Disease of Bone Therapeutics Market, Global, Branded vs. Generic Share, 2010 and 2018 44
Figure 25: Paget’s Disease of Bone Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2018 45
Figure 26: Paget’s Disease of Bone Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2018 46
Figure 27: Paget’s Disease of Bone Therapeutics Market, Treatment Flow Algorithm 48
Figure 28: Paget’s Disease of Bone, Market Drivers and Barriers 49
Figure 29: Hyperparathyroidism Therapeutics Market, Global, Revenue Forecasts ($m), 2002-2018 50
Figure 30: Hyperparathyroidism Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2018 52
Figure 31: Hyperparathyroidism Therapeutics Market, Global, Branded vs. Generic Share, 2010 and 2018 54
Figure 32: Hyperparathyroidism Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2018 55
Figure 33: Hyperparathyroidism Therapeutics Market, Global, Treatment Usage Patterns (millions), 2002-2018 56
Figure 34: Hyperparathyroidism Therapeutics Market, Treatment Flow Algorithm 58
Figure 35: Hyperparathyroidism, Market Drivers and Barriers 59
Figure 36: Bone Metastases Therapeutics Market, Global, Revenue Forecasts ($m), 2002-2018 61
Figure 37: Bone Metastases Therapeutics Market, Global, Revenue Analysis by Geography ($m), 2002-2018 62
Figure 38: Bone Metastases Therapeutics Market, Global, Branded vs. Generic Share, 2010 and 2018 64
Figure 39: Bone Metastases Therapeutics Market, Global, Annual Cost of Treatment ($), 2002-2018 65
Figure 40: Bone Metastases Therapeutics Market, Global, Treatment Usage Patterns (thousands), 2002-2018 66
Figure 41: Bone Metastases Therapeutics Market, Treatment Flow Algorithm 68
Figure 42: Bone Metastases, Market Drivers and Barriers 69
Figure 43: Bone Metabolism Therapeutics Market, Global, R&D Pipeline by Indication (%), 2011 70
Figure 44: Bone Metabolism Therapeutics Market, Global, R&D Pipeline by Phase (%), 2011 71
Figure 45: Bone Metabolism Therapeutics Market, Global, SWOT - Amgen Inc. 88
Figure 46: Bone Metabolism Therapeutics Market, Global, SWOT - Abbott Laboratories 89
Figure 47: Bone Metabolism Therapeutics Market, Global, SWOT - Genzyme Corporation 90
Figure 48: Bone Metabolism Therapeutics Market, Global, SWOT - Merck & Co., Inc. 92
Figure 49: Bone Metabolism Therapeutics Market, Global, SWOT - Novartis AG 94
Figure 50: Bone Metabolism Therapeutics Market, Global, Deals by Indication, 2009-2011 95
Figure 51: Bone Metabolism Therapeutics Market, M&A Deals, by Value ($m) 2009-2011 97
Figure 52: Bone Metabolism Therapeutics Market, M&A Deals, by Geography ($m) 2009-2011 99
Figure 53: Bone Metabolism Therapeutics Market, Licensing Deals, by Geography, 2009-2011 103
Figure 54: GBI Research Market Forecasting Model 110

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