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TS-1 (Colorectal Cancer) - Forecast and Market Analysis to 2023

Published: Nov-2014 | Format: PDF | GlobalData | Number of pages: 56 | Code: MRS - 3109


GlobalData has released its new PharmaPoint Drug Evaluation report, “TS-1 (Colorectal Cancer) - Forecast and Market Analysis to 2023”. Colorectal cancer (CRC) is the second leading cause of mortality among cancer patients in the world and is the third most diagnosed cancer globally, and thus represents a huge burden on healthcare systems. This report focuses on the current treatment landscape, unmet needs, current pipeline, and commercial opportunities in the colorectal cancer market, with coverage of multiple settings of the disease including neoadjuvant/adjuvant, first-, second-, third-line KRAS wild-type and mutation-positive, and fourth-line metastatic. In terms of targeted treatments, the metastatic CRC treatment landscape is mature, including the branded treatments Avastin (bevacizumab), Erbitux (cetuximab), and Vectibix (panitumumab), treatments that have extended the survival of metastatic patients compared to chemotherapy-only regimens. However, high unmet needs remain for the extension of survival of metastatic patients, and particularly those with KRAS mutation-positive disease, for whom the epidermal growth factor receptor (EGFR) inhibitors Erbitux and Vectibix are not recommended.

Taiho Pharmaceutical’s TS-1 is a combination chemotherapy that consists of tegafur (a pro-drug of 5-FU) and two agents, gimeracil and oteracil, which decrease the rate of degradation of the 5-FU anti-metabolite. TS-1 was originally approved for the treatment of gastric cancer in Japan in 1999.The drug subsequently gained Japanese approval for colorectal cancer in 2003, and is also approved for other indications, including NSCLC and breast cancer (Shirasaka, 2008). TS-1 is not approved for the treatment of CRC in the US or 5EU, and no late-stage trials for this indication are currently ongoing in these regions (Taiho Oncology, 2014).


- Overview of Colorectal Cancer, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on TS-1 including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for TS-1 for the top country from 2013 to 2023.
- Sales information covered for Japan.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Colorectal Cancer
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of TS-1 performance
- Obtain sales forecast for TS-1 from 2013-2023 in top country (Japan)

Table of Contents

1 Table of Contents 6
1.1 List of Tables 8
2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 10
2.3 Upcoming Related Reports 11
3 Disease Overview 12
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology 14
3.2 Clinical Staging 15
3.3 Symptoms 16
4 Disease Management 18
4.1 Diagnosis and Treatment Overview 18
4.1.1 Screening and Diagnosis 18
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 21
4.1.3 Clinical Practice 25
5 Competitive Assessment 32
5.1 Overview 32
6 TS-1 (Tegafur, Gimeracil, Oteracil) 34
6.1 Overview 34
6.2 Efficacy 35
6.3 Safety 35
6.4 SWOT Analysis 36
6.5 Forecast 36
7 Appendix 38
7.1 Bibliography 38
7.2 Abbreviations 43
7.3 Methodology 46
7.4 Forecasting Methodology 46
7.4.1 Diagnosed Colorectal Cancer Patients 46
7.4.2 Percent Drug-Treated Patients 47
7.4.3 General Pricing Assumptions 47
7.4.4 Average Body Weight and Surface Area Across the 8MM 48
7.4.5 Individual Drug Assumptions 49
7.4.6 Generic Erosion 49
7.5 Primary Research - KOLs Interviewed for this Report 50
7.6 Primary Research - Prescriber Survey 52
7.7 About the Authors 53
7.7.1 Analyst 53
7.7.2 Global Head of Healthcare 54
7.8 About GlobalData 55
7.9 Disclaimer 55

List of Tables

Table 1: TNM and Staging Classification System for CRC 16
Table 2: Symptoms of Colorectal Cancer 17
Table 3: Treatment Guidelines for CRC 22
Table 4: Most-Prescribed Neoadjuvant/Adjuvant Regimens for Early-Stage CRC in the Global Markets, 2013 23
Table 5: Most Prescribed Targeted Therapies for Metastatic CRC by Segment in the Global Markets, 2013 24
Table 6: Leading Treatments for CRC, 2014 33
Table 7: Product Profile - TS-1 35
Table 8: TS-1 SWOT Analysis, 2014 36
Table 9: Global Sales Forecasts ($m) for TS-1, 2013-2023 37
Table 10: Average Body Weight and Surface Area Across the 8MM 48
Table 11: High-Prescribing Physicians (non-KOLs) Surveyed, By Country 52

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